{"id":2123,"date":"2026-08-27T21:51:08","date_gmt":"2026-08-27T21:51:08","guid":{"rendered":"https:\/\/glacierems.com\/?page_id=2123"},"modified":"2026-08-28T04:57:16","modified_gmt":"2026-08-28T04:57:16","slug":"trazodone-drug-interactions","status":"publish","type":"page","link":"https:\/\/glacierems.com\/index.php\/trazodone-drug-interactions\/","title":{"rendered":"Trazodone Drug Interactions to Review by Name"},"content":{"rendered":"<style>\n.gz-trz-page{max-width:1120px;margin:0 auto;padding:22px 20px 68px;color:#113f4c;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:1.68;overflow-wrap:anywhere}.gz-trz-page *{box-sizing:border-box}.gz-trz-page h1,.gz-trz-page h2,.gz-trz-page h3{font-family:Georgia,serif;color:#113f4c}.gz-trz-hero{padding:clamp(28px,5vw,54px);background:#faf6f1;border-bottom:6px solid #d28243}.gz-trz-eyebrow,.gz-trz-review-label{margin:0 0 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#c4d7db;color:#587078;font-size:14px}@media(max-width:760px){.gz-trz-facts{grid-template-columns:repeat(2,minmax(0,1fr))}.gz-trz-process{grid-template-columns:1fr}}@media(max-width:640px){.gz-trz-page{padding:12px 12px 48px;font-size:17px}.gz-trz-reviewer{display:grid;grid-template-columns:96px minmax(0,1fr);align-items:start;padding:20px}.gz-trz-reviewer .gz-trz-review-text{min-width:0}.gz-trz-hero{padding:26px 20px}.gz-trz-media{min-height:170px}.gz-trz-facts{grid-template-columns:1fr 1fr}}\n.gz-trz-reviewer{display:grid;grid-template-columns:96px minmax(0,1fr);align-items:center}.gz-trz-review-text{min-width:0;width:100%}.gz-trz-reviewer a{overflow-wrap:anywhere}.gz-trz-review-profile{margin-top:9px!important}@media(max-width:640px){.gz-trz-reviewer{grid-template-columns:1fr;gap:14px;align-items:start;padding:20px}.gz-trz-reviewer img{justify-self:start}.gz-trz-review-text{width:100%}}\n<\/style>\n<article class=\"gz-trz-page\" data-page-id=\"trazodone-interactions\" data-role=\"ARTICLE\" data-canonical=\"https:\/\/glacierems.com\/index.php\/trazodone-drug-interactions\/\" data-robots=\"index,follow\" data-glacier-wave2-shell=\"layout-v2\">\n<style data-glacier-wave2-hero-style=\"background-v1\">[data-glacier-wave2-shell=\"layout-v2\"]{max-width:1180px;margin-inline:auto;}[data-glacier-wave2-shell=\"layout-v2\"]>section{margin-block:clamp(42px,6vw,72px);}[data-glacier-wave2-hero]{position:relative;isolation:isolate;overflow:hidden;margin-bottom:clamp(38px,5vw,68px)!important;padding:clamp(32px,5vw,64px)!important;border-radius:18px;box-shadow:0 18px 44px rgba(17,63,76,.13);}[data-glacier-wave2-hero]::after{content:\"\";position:absolute;z-index:1;inset:0;background:linear-gradient(90deg,rgba(244,249,250,.94) 0%,rgba(244,249,250,.82) 48%,rgba(17,63,76,.20) 100%);pointer-events:none;}[data-glacier-wave2-hero]>:not([data-glacier-wave2-backdrop]){position:relative;z-index:2;}[data-glacier-wave2-backdrop]{position:absolute;z-index:0;inset:0;width:100%;height:100%;object-fit:cover;filter:none;opacity:1;pointer-events:none;}[data-glacier-product-media]{display:block;width:min(100%,960px);height:auto;aspect-ratio:16\/9;object-fit:cover;margin:clamp(36px,5vw,64px) auto;border:1px solid #c4d7db;border-radius:18px;overflow:hidden;background:#fff;box-shadow:0 18px 42px rgba(17,63,76,.14);}[data-glacier-product-media]>img{display:block;width:100%;height:100%;object-fit:cover;}[data-glacier-wave2-hero] [data-glacier-product-media]{width:min(100%,760px);margin:clamp(30px,4vw,48px) auto 0;}@media(max-width:640px){[data-glacier-wave2-hero]{margin-bottom:38px!important;padding:26px 20px!important;border-radius:14px;}[data-glacier-wave2-hero]::after{background:linear-gradient(180deg,rgba(244,249,250,.94) 0%,rgba(244,249,250,.82) 68%,rgba(17,63,76,.18) 100%);}[data-glacier-wave2-shell=\"layout-v2\"]>section{margin-block:38px;}[data-glacier-product-media]{margin:34px auto;border-radius:14px;}}<\/style>\n<header class=\"gz-trz-hero\" data-glacier-wave2-hero=\"background-v1\"><img fetchpriority=\"high\" data-glacier-wave2-backdrop=\"glacier-trazodone-interaction-review.webp\" src=\"https:\/\/glacierems.com\/wp-content\/uploads\/2026\/08\/glacier-trazodone-interaction-review.webp\" alt=\"Pharmacist reviewing prescriptions and supplements for trazodone interactions\" width=\"1600\" height=\"900\" loading=\"eager\" decoding=\"async\"> <\/p>\n<p class=\"gz-trz-eyebrow\">Medication reconciliation \u00b7 Exact names matter<\/p>\n<h2>Trazodone Drug Interactions to Review by Name<\/h2>\n<p class=\"gz-trz-lead\">Trazodone drug interactions cannot be screened safely from a short list of categories. Prescribers and pharmacists need exact names, strengths, schedules and recent stop dates for prescriptions, over-the-counter products, supplements, alcohol and other substances. The result may be avoidance, monitoring, adjustment or a different treatment plan.<\/p>\n<figure data-glacier-product-media=\"product-glacier-trazodone-interaction-review.webp\" style=\"margin:clamp(36px,5vw,64px) 0;position:relative;z-index:2;overflow:hidden;border:1px solid #c4d7db;border-radius:18px;background:#fff;box-shadow:0 18px 42px rgba(17,63,76,.14);\"><img fetchpriority=\"high\" src=\"https:\/\/glacierems.com\/wp-content\/uploads\/2026\/08\/product-glacier-trazodone-interaction-review.webp\" alt=\"Desyrel and trazodone pharmacy packaging for Trazodone Drug Interactions to Review by Name\" width=\"1600\" height=\"900\" loading=\"eager\" fetchpriority=\"high\" decoding=\"async\" style=\"display:block;width:100%;height:auto;aspect-ratio:16\/9;object-fit:cover;\"><\/figure>\n<div class=\"gz-trz-facts\" aria-label=\"Page facts\"><span>Exact product names<\/span><span>Recent stop dates<\/span><span>Pharmacist review<\/span><span>No self-adjustment<\/span><\/div>\n<\/header>\n<style data-glacier-reviewer-style=\"canonical-v1\">@media(max-width:640px){[data-glacier-reviewer=\"canonical-v1\"]{flex-direction:column;align-items:flex-start!important;}[data-glacier-reviewer=\"canonical-v1\"]>div{min-width:0!important;width:100%;}}<\/style>\n<section data-glacier-reviewer=\"canonical-v1\" aria-label=\"Medical reviewer\" style=\"display:flex;align-items:center;gap:20px;padding:22px 24px;margin:0 0 30px;border:1px solid #c4d7db;border-top:4px solid #1f6c7b;background:#eef6f7;color:#113f4c;\"><img loading=\"lazy\" src=\"https:\/\/glacierems.com\/wp-content\/uploads\/2026\/08\/steven-chan-original.jpg\" alt=\"Steven Chan, MD, MBA\" width=\"96\" height=\"96\" loading=\"lazy\" decoding=\"async\" style=\"width:96px;height:96px;flex:0 0 96px;object-fit:cover;border-radius:50%;\"><\/p>\n<div style=\"min-width:0;flex:1;\">\n<p style=\"margin:0 0 4px;font-size:12px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#1f6c7b;\">Medically reviewed by<\/p>\n<p style=\"margin:0 0 5px;font-family:Georgia,serif;font-size:24px;line-height:1.25;font-weight:700;\"><a href=\"https:\/\/glacierems.com\/index.php\/expert-contributors\/steven-chan\/\">Steven Chan, MD, MBA<\/a><\/p>\n<p style=\"margin:0 0 5px;line-height:1.55;\">Psychiatry, addiction medicine and clinical informatics<\/p>\n<p style=\"margin:0 0 5px;line-height:1.55;\"><strong>Medical review completed August 27, 2026<\/strong><\/p>\n<p style=\"margin:0;\"><a href=\"https:\/\/glacierems.com\/index.php\/expert-contributors\/steven-chan\/\">View Glacier contributor profile<\/a><\/p>\n<\/div>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Build a complete interaction list<\/h2>\n<div class=\"gz-trz-process\">\n<div class=\"gz-trz-step\">\n<h3>1. Gather every product<\/h3>\n<p>Include prescriptions, OTC medicines, vitamins, herbs, alcohol and substances.<\/p>\n<\/div>\n<div class=\"gz-trz-step\">\n<h3>2. Add timing<\/h3>\n<p>Record current schedules plus start and stop dates.<\/p>\n<\/div>\n<div class=\"gz-trz-step\">\n<h3>3. Identify the prescribers<\/h3>\n<p>Note who manages each medicine and which pharmacy dispenses it.<\/p>\n<\/div>\n<div class=\"gz-trz-step\">\n<h3>4. Update before changes<\/h3>\n<p>Ask before starting, stopping or changing any product.<\/p>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Interaction categories in the label<\/h2>\n<div class=\"gz-trz-table-wrap\">\n<table class=\"gz-trz-table\">\n<caption>Why different combinations require different responses<\/caption>\n<thead>\n<tr>\n<th>Category<\/th>\n<th>Concern<\/th>\n<th>Clinical response<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>MAOIs<\/td>\n<td>Serotonin syndrome<\/td>\n<td>Contraindicated window<\/td>\n<\/tr>\n<tr>\n<td>Serotonergic drugs<\/td>\n<td>Additive serotonin<\/td>\n<td>Monitor or change<\/td>\n<\/tr>\n<tr>\n<td>QT-prolonging drugs<\/td>\n<td>Rhythm risk<\/td>\n<td>Avoid or assess<\/td>\n<\/tr>\n<tr>\n<td>Bleeding-risk drugs<\/td>\n<td>Added bleeding<\/td>\n<td>Monitor and plan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/section>\n<aside class=\"gz-trz-callout\">\n<h2>Recently stopped medicines still count<\/h2>\n<p>The label specifies separation around MAOIs, including relevant medicines such as linezolid or intravenous methylene blue. Do not assume a medicine is irrelevant because it left the active list yesterday. Give the clinician the exact stop date and reason.<\/p>\n<\/aside>\n<section class=\"gz-trz-section\">\n<h2>MAOIs create the clearest contraindication<\/h2>\n<p>DailyMed contraindicates trazodone during treatment with MAOIs and within the stated separation period because of serotonin-syndrome risk. Coordination matters in both directions when switching. The patient should not calculate the interval alone or restart an old prescription while another clinician is using linezolid or intravenous methylene blue.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Other serotonergic medicines can add risk<\/h2>\n<p>SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan and St. John\u2019s wort are examples named in prescribing information. The presence of one does not create a universal internet answer. The clinician evaluates purpose, dose, alternatives and how symptoms will be monitored.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>QT-prolonging combinations need heart context<\/h2>\n<p>The label advises avoiding trazodone with other medicines known to prolong QT. The risk discussion also uses personal and family rhythm history, fainting, recent heart attack and other factors. A pharmacy interaction alert is a prompt for clinical review, not a reason to ignore the medicine or stop it independently. <span class=\"gw2-inline-context\" data-gw2-inline-context=\"1\">For more detail on this decision, review <a href=\"\/index.php\/trazodone-safety\/\">trazodone safety<\/a>.<\/span><\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Bleeding risk often hides in nonprescription products<\/h2>\n<p>Aspirin and NSAIDs such as ibuprofen or naproxen may be taken without appearing on the prescription list. Antiplatelet medicines and anticoagulants also matter. The patient should report frequency and reason, not only the product name, and seek help for serious bleeding signs.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>CNS depressants can compound impairment<\/h2>\n<p>Alcohol, barbiturates and other central nervous system depressants can add to sedation and impaired judgment. Sleep aids, pain medicines and anxiety medicines may be relevant even when used only occasionally. The clinician needs the real pattern of use to discuss driving, falls and other safety-sensitive activities.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>CYP3A4 modifiers can alter exposure<\/h2>\n<p>Strong CYP3A4 inhibitors or inducers can affect trazodone levels, and the label gives clinicians adjustment considerations. This is not a self-dosing instruction. Antibiotics, antifungals, seizure medicines, HIV treatments and other products should be named exactly so the prescriber and pharmacist can determine whether the pathway changes. <span class=\"gw2-inline-context\" data-gw2-inline-context=\"2\">A related clinical question is covered in <a href=\"\/index.php\/trazodone-dosage\/\">trazodone dosage<\/a>.<\/span><\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>One pharmacy profile helps, but it is not complete by itself<\/h2>\n<p>A dispensing pharmacy may see many prescriptions but not supplements, samples, cash purchases, another pharmacy\u2019s medicines or substances. Bring a reconciled list to every relevant clinician and update it when something changes. Ask the pharmacist to explain alerts in plain language rather than dismissing or catastrophizing them.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Multiple prescribers need the same medication truth<\/h2>\n<p>Mental-health, primary-care, emergency, dental and specialty clinicians may each see only part of the list. Carry one current record and identify the dispensing pharmacies. When a new product is proposed, ask who will coordinate the final decision and monitoring. This prevents an interaction alert from becoming everyone\u2019s concern but no one\u2019s responsibility.<\/p>\n<\/section>\n<section class=\"gz-trz-section\">\n<h2>Pharmacy alerts need explanation rather than dismissal<\/h2>\n<p>An automated alert may be clinically important, manageable with monitoring or irrelevant to the exact situation. Ask the pharmacist what combination triggered it and what action is recommended. Then make sure the prescriber sees the same information. Neither ignoring every alert nor stopping every flagged medicine produces a safe medication plan.<\/p>\n<\/section>\n<nav class=\"gz-trz-nav\" aria-label=\"Trazodone topic pathways\">\n<h2>Explore related trazodone guidance<\/h2>\n<p>Use these related guides to explore the next question in your care.<\/p>\n<ul>\n<li><a href=\"\/index.php\/trazodone-safety\/\">trazodone safety<\/a> <span><\/span><\/li>\n<li><a href=\"\/index.php\/trazodone-dosage\/\">trazodone dosage<\/a> <span><\/span><\/li>\n<li><a href=\"\/index.php\/trazodone-side-effects\/\">trazodone side effects<\/a> <span><\/span><\/li>\n<\/ul>\n<\/nav>\n<section class=\"gz-trz-section gz-trz-faq\">\n<h2>Questions readers ask after this review<\/h2>\n<details>\n<summary>What medicines should not be taken with trazodone?<\/summary>\n<p>MAOIs are contraindicated in the label\u2019s separation window; many other products require individualized review rather than a universal ban.<\/p>\n<\/details>\n<details>\n<summary>Do supplements count as interactions?<\/summary>\n<p>Yes. St. John\u2019s wort and tryptophan are examples named in patient information, and other supplements should be disclosed.<\/p>\n<\/details>\n<details>\n<summary>Does ibuprofen matter?<\/summary>\n<p>NSAIDs can add to bleeding risk, so tell the clinician and pharmacist how often and why you use them.<\/p>\n<\/details>\n<details>\n<summary>Can alcohol interact with trazodone?<\/summary>\n<p>Alcohol can add to central nervous system depression and impairment and should be included in the safety discussion.<\/p>\n<\/details>\n<details>\n<summary>Should I stop an interacting medicine myself?<\/summary>\n<p>No. Contact the prescriber or pharmacist; abrupt changes can create new risks.<\/p>\n<\/details>\n<\/section>\n<section class=\"gz-trz-sources\">\n<h2>Primary and authoritative sources<\/h2>\n<ul>\n<li><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=596c3f00-1504-eaed-e063-6294a90a08bb\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" referrerpolicy=\"no-referrer\">DailyMed, U.S. National Library of Medicine: Trazodone hydrochloride tablet prescribing information<\/a> \u2014 label updated August 19, 2026; checked August 27, 2026.<\/li>\n<li><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a681038.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" referrerpolicy=\"no-referrer\">MedlinePlus, U.S. National Library of Medicine: Trazodone drug information<\/a> \u2014 checked August 27, 2026.<\/li>\n<\/ul>\n<\/section>\n<p class=\"gz-trz-disclaimer\">Educational information for human care only. This page does not diagnose a condition, guarantee a prescription, select an individual dose, replace a clinician or provide veterinary advice.<\/p>\n<\/article>\n<p><script type=\"application\/ld+json\" data-glacier-wave2-schema>{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/glacierems.com\/index.php\/trazodone-drug-interactions\/#webpage\",\"url\":\"https:\/\/glacierems.com\/index.php\/trazodone-drug-interactions\/\",\"name\":\"Trazodone Interactions: Medicines and Risks to Review\",\"headline\":\"Trazodone Drug Interactions to Review by Name\",\"description\":\"Review trazodone interactions, why exact medicine names and stop dates matter, and when serotonin, rhythm, bleeding or sedation risks change 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